FREE D-AMINO-ACID AND L-AMINO-ACID IN VENTRICULAR CEREBROSPINAL-FLUIDFROM ALZHEIMER AND NORMAL SUBJECTS

Authors
FISHER G LORENZO N ABE H FUJITA E FREY WH EMORY C DIFIORE MM DANIELLO A
Citation
G. Fisher et al., FREE D-AMINO-ACID AND L-AMINO-ACID IN VENTRICULAR CEREBROSPINAL-FLUIDFROM ALZHEIMER AND NORMAL SUBJECTS, Amino acids, 15(3), 1998, pp. 263-269
Citations number
22
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
15
Issue
3
Year of publication
1998
Pages
263 - 269
Database
ISI
SICI code
0939-4451(1998)15:3<263:FDALIV>2.0.ZU;2-D
Abstract
Free D-Ser, D-Asp and total B-amino acids were significantly higher (p < 0.05) in Alzheimer (AD) ventricular CSF than in normal CSF. There w as no significant difference in the total L-amino acids between AD and normal CSF, but L-Gln and L-His were significantly higher (p < 0.05) in AD-CSF, The higher concentrations of these D- and L-amino acids in AD ventricular CSF could reflect the degenerative process that occurs in Alzheimer's brain since ventricular CSF is the repository of amino acids from the brain.