STEREOISOMERS OF 3-(2,3-DIHYDROBENZOFURAN-2-YL)QUINUCLIDINE - PREPARATION AND MUSCARINIC RECEPTOR AFFINITIES

Authors
JOHANSSON G BRISANDER M SUNDQUIST S HACKSELL U
Citation
G. Johansson et al., STEREOISOMERS OF 3-(2,3-DIHYDROBENZOFURAN-2-YL)QUINUCLIDINE - PREPARATION AND MUSCARINIC RECEPTOR AFFINITIES, Chirality, 10(9), 1998, pp. 813-820
Citations number
31
Categorie Soggetti
Chemistry Medicinal","Chemistry Analytical","Chemistry Inorganic & Nuclear","Pharmacology & Pharmacy
Journal title
Chirality → ACNP
ISSN journal
08990042
Volume
10
Issue
9
Year of publication
1998
Pages
813 - 820
Database
ISI
SICI code
0899-0042(1998)10:9<813:SO3-P>2.0.ZU;2-3
Abstract
The four stereoisomers of the antimuscarinic 3-(2,3-dihydrobenzofuran- 2-yl) quinuclidine have been prepared by a method involving chromatogr aphic separation of the racemic diastereoisomers as borane complexes. The relative and absolute configurations of the stereoisomers were det ermined by X-ray crystallographic methods. The crystal structure of (2 'R,3R)-3-(2,3-dihydrobenzofuran-2-yl) quinuclidine . HCl . H2O contain s two independent molecules with different conformations of both the q uinuclidine moiety and the dihydrofuran ring. (C) 1998 Wiley-Liss, Inc .