Da. Mark et al., BOTH CD80 AND CD86 COSTIMULATORY MOLECULES REGULATE ALLERGIC PULMONARY INFLAMMATION, International immunology (Print), 10(11), 1998, pp. 1647-1655
We examined the roles of CD80 (B7-1) and CD86 (B7-2) in a model of all
ergic pulmonary inflammation and airway hyper-responsiveness (AHR) by
selectively inhibiting either CD80 or CD86. Inhibition of co-stimulati
on by either CD80 or CD86 affected multiple parameters of the allergic
response. Specifically, blockade of either CD80 or CD86 in ovalbumin-
sensitized and challenged mice resulted in reduced expression of IL-2R
alpha (CD25) on CD4(+) T lymphocytes, decreased airway eosinophilia,
lower serum IgE production and diminished AHR. Importantly, blockade o
f CD80 and CD86 inhibited production of IL-4 and IL-2, and enhanced IF
N-gamma production. Our observations support a role for both CD80- and
CD86-mediated co-stimulation in development of allergic pulmonary inf
lammation.