THE PHARMACOKINETICS OF INTRAVENOUS ESTRADIOL - A PRELIMINARY-STUDY

Estradiol USP was extemporaneously compounded for intravenous administ ration. Eight postmenopausal women were randomized to receive one of f our estradiol dosages. Serum estradiol concentrations were determined at frequent intervals after single bolus dosing. The concentration-tim e profile was stripped and fit, and pharmacokinetic values were genera ted. Approximate dosage proportionality was seen with area under the c urve, the terminal half-life was 27.45 +/- 5.65 minutes, and volume of distribution was very low (0.082 +/- 0.015 L/kg). Estradiol was well tolerated by all study participants.