Thrombotic thrombocytopenic purpura (TTP) occurs in association with a
wide variety of disorders including infections, connective tissue dis
eases, and solid organ tumors. It also may coincide with administratio
n of drugs such as mitomycin, metronidazole, oral contraceptives, cycl
osporine, and many others. We report the occurrence of TTP in a patien
t shortly after the initiation of ticlopidine.