REVERSAL OF SEDATIVE AND CLINICOPHYSIOLOGICAL EFFECTS OF EPIDURAL XYLAZINE AND DETOMIDINE WITH ATIPAMEZOLE AND YOHIMBINE IN BUFFALOS (BUBALUS-BUBALIS)

The sedative and clinicophysiological effects of either xylazine (0.1 mg/kg) or detomidine (50 mu g/kg) administered epidurally to groups of five buffaloes were reversed by the intravenous administration of eit her yohimbine (0.125 mg/kg) or atipamezole (10 mu g/kg). Epidural xyla zine or detomidine produced bradycardia, respiratory depression, rumin al stasis and hypothermia and these effects were completely reversed w ithin five to 15 minutes after the intravenous administration of atipa mezole or yohimbine, with no signs of excitement or resedation. Atipam ezole reversed the effects of xylazine or detomidine more rapidly than yohimbine.