COAGULATION ALTERATIONS DUE TO LOCAL FIBRINOLYTIC THERAPY WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR (RT-PA) IN PATIENTS WITH PERIPHERAL ARTERIAL OCCLUSIVE DISEASE

Purpose: To determine the systemic effects of local fibrinolytic thera py with low-dose recombinant tissue-type plasminogen activator (rt-PA) . Methods: Ten patients received intrathrombal infusion of 20 mg rt-PA and heparin for local thrombolysis and had subsequent percutaneous tr ansluminal angioplasty (PTA). Eight controls underwent PTA and receive d heparin alone. We measured t-PA, D-Dimer, and fibrinogen levels befo re, directly after, and 20, 40, and 60 min and 24 hr after therapy. Re sults: In the thrombolysis group the t-PA level peaked immediately aft er infusion and then declined within 1 hr. D-Dimer increased and remai ned elevated, whereas in the control group only t-PA levels increased, and only after 24 hr. Fibrinogen remained within the normal range in both groups. Eight of ten patients in the thrombolysis group and seven of eight with PTA had clinical improvement after the procedure. Concl usions: The increase in D-Dimer in the rt-PA group indicates a good lo cal fibrinolytic effect. The fact that fibrinogen levels remained unch anged indicates that there is a lack of systemic fibrinogenolysis.