APPLICATION OF NMR-SPECTROSCOPY IN BIOCHEMICAL-STUDIES OF TUMOR-CELLSSENSITIVE AND RESISTANT TO ANTICANCER DRUGS

Drug resistance is a prominent problem of cancer therapy Differences i n quantity and quality of many metabolites in normal and malignant cel ls and their changes after treatment by anticancer drugs can be detect ed by nuclear magnetic resonance (NMR) both in vivo and in vitro. The results of in vivo and in vitro H-1, C-13, F-19 and P-31 NMR spectrosc opy and their correlation with the degree of resistance to anticancer drugs are discussed. Monitoring of treatment and development of drug r esistance by this non-invasive method could be useful not only in canc er research related to drug resistance but also in clinical medical on cology.