DILUTION AND STORAGE OF BOTULINUM TOXIN

BACKGROUND. There has been an ongoing controversy as to the best dilut ion for botulinum ton:in for use in cosmetic applications. Recommended dilutions have ranged from 1 mi per vial to 10 mi per vial. There has also been much discussion on the diluent, i.e., preserved versus unpr eserved saline, to be used and on storage time of the material after d ilution. OBJECTIVES. The objective of this paper is to examine the lit erature and experience of practitioners in the field to try to resolve some of the questions concerning dilution and storage of botulinum to xin CONCLUSIONS. Although there is great variation in the dilutions ad opted by various physicians, much of this is a matter of personal pref erence. If does seem to appear that most clinicians use a dilution nea r 2.5 to 3.0 ml.per vial and three-quarters of them limit the storage of the diluted product to 1 week or less. (C) 1998 by the American Soc iety for Dermatologic Surgery, Inc.