Antibiotic prophylaxis for the prevention of infective endocarditis re
lated to dental therapy is a widespread therapeutic intervention. Rece
ntly, updated and revised guidelines on this treatment modality have b
een set forth in the form of consensus statements. It is evident that
the risk of spontaneous bacteremia is much greater in a diseased oral
cavity than it is in a healthy oral cavity. Perhaps most important in
the prevention of infective endocarditis is early identification of at
-risk patients and prompt referral to oral health specialists for comp
rehensive evaluation and treatment. The judicious use of antibiotic pr
ophylaxis for prevention of infective endocarditis, in conjunction wit
h optimal oral health care, should serve to minimize the adverse effec
ts of antibiotic therapy and at the same time reduce the significant m
orbidity and mortality associated with these infections.