AFFECTED SIB-PAIR METHODS FOR DETECTING LINKAGE TO DICHOTOMOUS TRAITS- REVIEW OF THE METHODOLOGY

Affected sib-pair methods are commonly used to detect linkage to dicho tomous traits. This review discusses the principles underlying affecte d sib-pair tests for linkage and the merits of sib-pair methods relati ve to traditional fod score methods. Extensions of the methods to incl ude other typed unaffected relatives, extra affected siblings, and mul tiple marker and disease loci are reviewed together with an investigat ion of the most effective ways to perform genome scans.