EFFECTS OF LOW-MOLECULAR-WEIGHT ALUMINUM COMPLEXES ON BRAIN-TISSUE CALCIUM HOMEOSTASIS

The in vitro effects of low-molecular-weight aluminum complexes (citra te, lactate, and ATP complex) on the Ca2+ uptake and aluminum-induced lipid peroxidation of brain tissue show that the modification of the c alcium homeostasis is determined by the nature of the ligand and that there is no correlation between the aluminum-induced Lipid peroxidatio n and the Ca2+ uptake. The same characteristics have been shown by a s imilar study performed with Ehrlich carcinoma cells. The electrophoret ic analyses of the aluminum lactate-albumin and aluminum lactate-ATP i nteractions indicate an aluminum transfer from the lactate to the albu min and Am ligands. The increased Ca2+ uptake when ATP is present in t he incubation medium with aluminum citrate and aluminum lactate corrob orates the suggested mediator role of ATP in cellular calcium homeosta sis modification induced by iron.