RECENT ADVANCES IN N-PROTECTION FOR AMINO SUGAR SYNTHESIS

Recent synthetic efforts in the construction of oligosaccharides, glyc oproteins, glycolipids and other glycoconjugates containing a variety of 2-amino-2-deoxy sugars have led to the development of new methods f or nitrogen protection. These new nitrogen-protecting groups have been removed from substrates using mild and often chemoselective condition s. in this micro-review the preparation, present uses, and deprotectio n of amino sugar derivatives employing these new agents are described. Applications of phthalimidse with electron-withdrawing groups includi ng the tetrachlorophthaloyl (TCP), dichlorophthaloyl (DCPhth), dithias uccinoyl (Dts), N-pent-4-enoyl and N,N-diacetyl functionalities are di scussed.