BIOTRANSFORMATION OF THE SESQUITERPENOID (-GAMMA-GURJUNENE USING A PLANT-PATHOGENIC FUNGUS, GLOMERELLA-CINGULATA, AS A BIOCATALYST())

The biotransformation of a sesquitepenod which possesses a guaiane ske leton, (+)-gamma-gujunene has been investigated using the plant pathog enic fungus, Glomerella cingulata as a biocatalyst. (+)-gamma-Gurjunen e was oxidized at the double bond of the isopropenyl group to (1S,4S,7 R,10R)-5-guaien-11,13-diol and in addition oxidized at the C-10 positi on to (1S,4S,7R,10S)-5-guaien-10,11,13-triol. The structures of the me tabolic products have been elucidated on the basis of their spectral d ata. (C) 1998 Elsevier Science Ltd. All rights reserved.