BIS(GUANIDINIUM) RECEPTORS AS RIBONUCLEASE ACTIVE-SITE MODEL SYSTEMS - STRUCTURAL-CHANGES AND SOLVENT EFFECT

Authors
OOST T FILIPPAZZI A KALESSE M
Citation
T. Oost et al., BIS(GUANIDINIUM) RECEPTORS AS RIBONUCLEASE ACTIVE-SITE MODEL SYSTEMS - STRUCTURAL-CHANGES AND SOLVENT EFFECT, Liebigs Annalen, (5), 1997, pp. 1005-1011
Citations number
32
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
5
Year of publication
1997
Pages
1005 - 1011
Database
ISI
SICI code
0947-3440(1997):5<1005:BRARAM>2.0.ZU;2-L
Abstract
Various bis(guanidinium) compounds have been synthesized and their abi lities to cleave the RNA model compound HPNPP have been tested in acet onitrile and in water. Depending on the spacer length, the substitutio n of the guanidinium groups, and the presence of an internal base, dif ferent rate constants for the transesterification of HPNPP are observe d in these two media. The steroid derived bis(guanidinium) compound 12 was identified as a superior system.