MULTIANODE DETECTION IN ELECTROSPRAY-IONIZATION TIME-OF-FLIGHT MASS-SPECTROMETRY

An electrospray ionization ion source coupled to a time-of-night mass analyzer incorporating a multi-anode time-to-digital converter is desc ribed. High-speed data acquisition (kHz mass spectral acquisition) rat es are achieved. The four-anode detector produces a significant increa se in detection/counting efficiency over that for a single-anode detec tor. In this work a 2.5 times increase in detection efficiency is demo nstrated. The multi-anode detector is also used as a diagnostic tool t o optimize transmission of the ion optics. (C) 1998 American Society f or Mass Spectrometry.