Laparoscopic partial nephrectomy (LPN) remains a technically challengi
ng procedure largely because of the lack of methods for obtaining cons
istent parenchymal hemostasis. The objective of this study was to dete
rmine if the extent of resection influences the ability of the harmoni
c scalpel to achieve hemostasis and to define the cases in which the h
armonic scalpel is appropriate for LPN, Thirty LPNs were performed in
a 25-kg domestic pig model. The blunt blade of the laparoscopic harmon
ic scalpel (LaparoSonic Coagulating Shears; Ethicon Endo-Surgery, Cinc
innati, OH) at power level 5 was used to divide the parenchyma, Contro
l of the renal hilar vessels was not obtained. Three standardized type
s of resections were performed: I = peripheral wedge biopsy; II = uppe
r- or lower-pole nephrectomy; and III = heminephrectomy, Bleeding was
graded on a scale from 0 to 4: 0 = no hemostasis; 1 = steady bleeding;
2 = moderate bleeding; 3 = parenchymal oozing; and 4 = dry. Hemostasi
s grades of 2 or less were clinically significant bleeding necessitati
ng supplemental coagulation. The mean hemostasis scores showed a signi
ficant (P < 0.02) trend toward inadequate hemostasis with increasing e
xtent of resection: 3.3 for Type I, 3.0 for Type II, and 2.4 for Type
III. The percent of kidneys with grade 2 bleeding or worse was 9% for
Type I surgery, 25% for Type II, and 57% for Type III. Successful hemo
stasis with the harmonic scalpel correlates with the extent of parench
ymal resection in the porcine model. Most wedge excisions can be done
with the harmonic scalpel alone, whereas larger resections necessitate
supplemental coagulation. On the basis of this study, heminephrectomi
es with the harmonic scalpel are not recommended because of the high i
ncidence of significant hemorrhage.