SYNTHESIS, STRUCTURE ELUCIDATION AND ANTIMICROBIAL ACTIVITY OF SOME 3-HYDROXY-2-NAPHTHOIC ACID HYDRAZIDE DERIVATIVES

In this study, some 1,4-disubstituted thiosemicarbazide, 1,2,4-triazol e and 1,3,4-thiadiazole type novel compounds derived from 3-hydroxy-2- naphthoic acid hydrazide were synthesized to screen for their antimicr obial activity. The structures of these substances were elucidated usi ng elemental analysis and UV, H-1 NMR, and mass spectral methods. All of these compounds were tested in vitro for their antibacterial and an tifungal activity. (C) 1998 Elsevier Science S.A. All rights reserved.