PYRAZOLE ANALOGS OF PRAZOSIN

Authors
ERMONDI G BOSCHI D DISTILO A TIRONI C GASCO A
Citation
G. Ermondi et al., PYRAZOLE ANALOGS OF PRAZOSIN, Il Farmaco, 53(7), 1998, pp. 519-524
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
53
Issue
7
Year of publication
1998
Pages
519 - 524
Database
ISI
SICI code
0014-827X(1998)53:7<519:>2.0.ZU;2-H
Abstract
A series of analogues of prazosin, in which 1-methyl or 1-phenylpyrazo le moieties were substituted for the furan ring, were synthesized and studied for their alpha(1)-adrenoceptor antagonist activity. The role of the five member heterocyclic substructures in determining the affin ity for the alpha(1)-receptor is briefly discussed. (C) 1998 Elsevier Science S.A. All rights reserved.