D. Milburn et al., SEQUENCES ANNOTATED BY STRUCTURE - A TOOL TO FACILITATE THE USE OF STRUCTURAL INFORMATION IN SEQUENCE-ANALYSIS, Protein engineering (Print), 11(10), 1998, pp. 855-859
With the aim of bridging the gap between protein sequence and structur
al analyses, we have developed a tool to aid the identification of new
protein sequences by recognizing distant homologues using structural
information. The tool generates sequence annotated by structure (SAS)
files, applying structural information derived from structural analyse
s to a given protein sequence. A World Wide Web interface allows a giv
en sequence to be submitted either for structural annotation or, where
its structure is unknown, for search and alignment against sequences
of known structure, In both cases, SAS will colour residues in the seq
uence of known structure according to a selection of properties, inclu
ding secondary structure, interatomic contacts anti active site inform
ation. SAS can also be used to inspect properties of a single structur
e.