GENETIC AND PHYSICAL DELINEATION OF THE REGION OF THE MOUSE DEAFNESS MUTATION SHAKER-2

Authors
WAKABAYASHI Y KIKKAWA Y MATSUMOTO Y SHINBO T KOSUGI S CHOU D FURUYA M JISHAGE K NODA T YONEKAWA H KOMINAMI R
Citation
Y. Wakabayashi et al., GENETIC AND PHYSICAL DELINEATION OF THE REGION OF THE MOUSE DEAFNESS MUTATION SHAKER-2, Biochemical and biophysical research communications, 234(1), 1997, pp. 107-110
Citations number
18
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
234
Issue
1
Year of publication
1997
Pages
107 - 110
Database
ISI
SICI code
0006-291X(1997)234:1<107:GAPDOT>2.0.ZU;2-B
Abstract
A total of 951 backcross progeny have been obtained from a backcross s egregating for the mouse deafness mutation, shaker-2(sh-2). Linkage an alysis provides a detailed genetic map in the vicinity of sh-2 which c omprises 40 backcross mice identified as recombinant within a 4 cM reg ion. This allows construction of a contig consisting of 21 BAC clones across an approximately 700-kb region of sh-2. This covers the entire nonrecombinant region of sh-2 and is therefore useful to facilitate th e identification of genes in the sh-2 region. (C) 1997 Academic Press.