PRIMARY SINONASAL MUCOSAL MELANOMA - 3 DIFFERENT THERAPEUTIC APPROACHES TO INOPERABLE LOCAL DISEASE OR RECURRENCE AND A REVIEW OF THE LITERATURE

Citation
Go. Demeerleer et al., PRIMARY SINONASAL MUCOSAL MELANOMA - 3 DIFFERENT THERAPEUTIC APPROACHES TO INOPERABLE LOCAL DISEASE OR RECURRENCE AND A REVIEW OF THE LITERATURE, Melanoma research, 8(5), 1998, pp. 449-457
Citations number
52
Categorie Soggetti
Oncology,"Dermatology & Venereal Diseases","Medicine, Research & Experimental
Journal title
ISSN journal
09608931
Volume
8
Issue
5
Year of publication
1998
Pages
449 - 457
Database
ISI
SICI code
0960-8931(1998)8:5<449:PSMM-3>2.0.ZU;2-5
Abstract
Sinonasal melanoma is an uncommon disease with a bad prognosis and a h igh local recurrence rate, The use of radiotherapy in such conditions remains controversial, A review of the literature is presented in an a ttempt to answer some of the questions regarding therapeutic options. Data on incidence, aetiology, pathology and prognosis are also provide d. Case studies are reported of three patients with sinonasal melanoma referred to our department in a relatively short time period and need ing radiotherapy as a single treatment modality, using a conformal thr ee-dimensional treatment technique, One patient was also treated with temporary I-125 seeds, while another was treated using intensity modul ation. Both intensity modulation and temporary I-125 seeds are feasibl e techniques, providing satisfactory dose distributions encompassing t he tumour volume while sparing critical structures, Surgery remains th e treatment of choice for sinonasal melanoma. Radiotherapy should be u sed postoperatively and is a good alternative in cases of inoperable d isease, Adjacent critical structures limit the radiation dose to the t umour area, especially when high fraction doses are used. Therefore, b eam intensity modulation and I-125 seeds can be used to increase the t umour dose without exceeding the radiation tolerance of the surroundin g structures. (C) 1998 Lippincott Williams & Wilkins.