TYROSINE KINASE-ACTIVITY IS ASSOCIATED WITH CD44 IN HUMAN NEUTROPHILS

CD44 appears to be involved in signal transduction, however, the mecha nism of this function is unclear. Protein kinase activity was detected in neutrophils associated with CD44. Most of the protein kinase activ ity associated with these antigens was tyrosine kinase activity. Src f amily kinases lyn and hck were found to account for much of the associ ated tyrosine kinase activity. The data suggest that associated tyrosi ne kinase activity may play a pole in signal transduction from CD44 in neutrophils to regulate other cell functions. (C) 1998 Federation of European Biochemical Societies.