Y. Murakawa et al., ASTROCYTOMA AND B-CELL LYMPHOMA DEVELOPMENT IN A MAN WITH A P53 GERMLINE MUTATION, Japanese Journal of Clinical Oncology, 28(10), 1998, pp. 631-637
We report a case with a germline mutation of the p53 gene develpoing b
oth a non-Hodgkin's lymphoma and an astrocytoma. The astrocytoma could
be cured by two operations and combined chemotherapy but 33 months af
ter the onset of the disease, he suffered from a diffuse, large cell c
entroblastic malignant lymphoma of B-cell lineage. In spite of clear r
earranged fragments observed with IgH and c-MYC gene probes, we could
not diagnose a Burkitt's lymphoma morphologically. The malignant lymph
oma was chemoresistant and the patient died of multi-organ failure. He
was confirmed to have a germline mutation of the p53 gene by analysis
of c-DNA from peripheral lymphocytes and loss of heterozygosity (LOH)
of p53 was evident in the lymphoma. The results were suggestive of th
e Li-Fraumeni syndrome (LFS), a rare autosomal dominantly inherited sy
ndrome with a germline mutation of p53 gene and diverse malignancies,
but this could not be confirmed in the present case. Alternatively, a
de novo mutation could have been involved.