SECRETIN AND GASTRIC LIPASE SECRETION

Background: Gastric lipase secretion is stimulated by gastrin in plasm a, but its regulation by secretin is unknown. Methods: In 7 normal per sons we investigated the effect of exogenous secretin on the output of gastric lipase stimulated by intravenous gastrin-17. The gastric cont ent was measured using a nasogastric tube for aspiration. The quantita tive lipase secretion was measured by an enzyme-linked immunosorbant a ssay (ELISA) and the lipolytic activity by a kinetic assay. Plasma con centrations of secretin and gastrin were measured by radioimmunoassay. Results: Gastric lipase secretion (the quantity as well as the lipoly tic activity) was significantly stimulated by gastrin. In response to secretin infusion, the lipolytic activity increased as acid secretion decreased. Conclusion: Secretin in postprandial concentrations does no t influence the quantitative gastric lipase secretion stimulated by ga strin, but it increases lipolytic activity due to inhibition of acid s ecretion.