(S)-NAPROXEN(R) AS A DERIVATIZING AGENT TO DETERMINE ENANTIOMERIC EXCESS OF CYANOHYDRINS BY HPLC

Authors
SOLIS A LUNA H PEREZ HI MANJARREZ N SANCHEZ R GUTIERREZ A
Citation
A. Solis et al., (S)-NAPROXEN(R) AS A DERIVATIZING AGENT TO DETERMINE ENANTIOMERIC EXCESS OF CYANOHYDRINS BY HPLC, Tetrahedron letters, 39(48), 1998, pp. 8759-8762
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
48
Year of publication
1998
Pages
8759 - 8762
Database
ISI
SICI code
0040-4039(1998)39:48<8759:(AADAT>2.0.ZU;2-P
Abstract
An easy, inexpensive and accurate method to determine enantiomeric exc ess of cyanohydrins is described. The method consists in derivatizatio n of cyanohydrins with (S)-naproxen(R) chloride and the products analy zed by HPLC. The results of enantiomeric excess so determined are simi lar to those obtained with [Eu(hfc)(3)], as a chiral shift reagent, an d analysis by H-1-NMR of the cyanohydrins. (C) 1998 Elsevier Science L td. All rights reserved.