SELECTIVE AND CONTROLLED HYDROLYSIS OF CHLOROPEPTIN I - HIV-1 INTEGRASE ACTIVITY OF FRAGMENTS

Authors
SINGH SB JAYASURIYA H HAZUDA DL FELOCK P HOMNICK CF SARDANA M PATANE MA
Citation
Sb. Singh et al., SELECTIVE AND CONTROLLED HYDROLYSIS OF CHLOROPEPTIN I - HIV-1 INTEGRASE ACTIVITY OF FRAGMENTS, Tetrahedron letters, 39(48), 1998, pp. 8769-8770
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
48
Year of publication
1998
Pages
8769 - 8770
Database
ISI
SICI code
0040-4039(1998)39:48<8769:SACHOC>2.0.ZU;2-G
Abstract
Selective amide bond cleavages of chloropeptin I were accomplished usi ng trifluoroacetic acid (TFA), and a mixture of acetic acid, hydrochlo ric acid and thioglycolic acid. The hydrolysis products maintaining th e bicyclic core retained HIV-1 integrase inhibitory activity similar t o that of the chloropeptin I. The hydrolysis products and their HIV-1 integrase activities are described. (C) 1998 Elsevier Science Ltd. All rights reserved.