TETRAKIS(DIMETHYLAMINO)ETHYLENE (TDAE) AS A USEFUL REDUCTANT OF SOME CHLORODIFLUOROMETHYLATED KETONES - A NEW APPROACH FOR THE SYNTHESIS OFALPHA,ALPHA-DIFLUOROKETONE DERIVATIVES

Authors
BURKHOLDER C DOLBIER WR MEDEBIELLE M NDEDI A
Citation
C. Burkholder et al., TETRAKIS(DIMETHYLAMINO)ETHYLENE (TDAE) AS A USEFUL REDUCTANT OF SOME CHLORODIFLUOROMETHYLATED KETONES - A NEW APPROACH FOR THE SYNTHESIS OFALPHA,ALPHA-DIFLUOROKETONE DERIVATIVES, Tetrahedron letters, 39(48), 1998, pp. 8853-8856
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
48
Year of publication
1998
Pages
8853 - 8856
Database
ISI
SICI code
0040-4039(1998)39:48<8853:T(AAUR>2.0.ZU;2-S
Abstract
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective re ductant of chlorodifluoromethylated ketones 1-3. The generated alpha,a lpha-difluoroacetyl anion was trapped with several aldehydes 4-7, unde r mild conditions, to give the corresponding 2,2-difluoro-3-hydroxy ke tone derivatives 8-13, in moderate yields. (C) 1998 Published by Elsev ier Science Ltd. All rights reserved.