The aim of this study was to evaluate the usefulness of head up tilt t
esting in patients with syncope of unknown origin. Between January 199
4 and September 1995, 93 patients were referred for tilt table assessm
ent due to recurrent syncope of uncertain etiology. There were 42 men
(mean age 59 years). Thirty healthy volunteers served as a control gro
up. The specific protocol used involved an initial period of supine re
st for 15'. Baseline blood pressure (BP) and heart rate (HR) were reco
rded. This was followed by a tilt to 80 degrees for 30', BP and HR wer
e measured every minute during the procedure. The test was considered
positive when symptoms appeared associated with one of the following r
esponses: systolic BP decreased more than 30 mmHg (vasodepressor), bra
dicardia or asystolia for up to 3 '' (cardioinhibitory) or mixed. Resu
lts: The tilt test was positive in 31 of 93 patients (33%). Seventeen
patients (55%) had a vasodepressor response, 3 patients (9%) a cardioi
nhibitory response and 11 patients (36%) mixed responses. The clinical
manifestations were 62% near syncope, 19% syncope and the other patie
nts presented dypsnea or dizziness. The symptoms disappeared promptly
after adopting the supine position. None of the 30 healthy volunteers
developed symptoms. We conclude that head up tilt test is a safe and e
ffective method for identifying a neurocardiogenic origin in a syncope
of uncertain etiology.