8 DRUGS IN ONE-DAY CHEMOTHERAPY IN A NONFAMILIAL BILATERAL RETINOBLASTOMA WITH RECURRENT CEREBROSPINAL-FLUID METASTASES

A case of bilateral retinoblastoma with recurrent cerebrospinal fluid (CSF) metastases is presented. The patient underwent left eye enucleat ion and received external beam radiotherapy to the right eye. A sequen tial combination chemotherapy, including cyclophosphamide, vincristine , carboplatin, and etoposide with intrathecal drug administration, was then adopted. During treatment a relapse within the central nervous s ystem (CNS) occurred. The ''8-in-1-day'' chemotherapy, wed in our depa rtment in medulloblastoma patients with CSF involvement was then consi dered. The patient received 8 total courses, each with intrathecal dru g administration No toxicity was experienced. The patient is alive and free from CSF metastases after a period of 48 months and has been in continuous complete remission (CCR) for 41 months. The authors conclud e that the use of the ''8-in-1'' regimen is feasible and can be used i n retinoblastoma patients with recurrent CSF metastases.