N. Fixler et al., REGIOSELECTIVE ELECTROPHILIC SUBSTITUTION OF 2-HYDROXY AND 2-METHOXY SUBSTITUTED ACRIDINES - APPLICATION TO THE SYNTHESIS OF PYRIDO[2,3,4-MN]ACRIDINE, Synthetic communications, 27(13), 1997, pp. 2311-2324
The presence of a hydroxy or methoxy group in position 2 of acridine d
irects the electrophilic substitution by formaldehyde in methane sulfo
nic acid to position 1. This reactivity is applied to the synthesis of
pyrido[2,3,4-m,n]acridine.