A NOVEL ROUTE TO PYRIMIDINE ISODIDEOXYNUCLEOSIDES VIA MICHAEL-TYPE ADDITION ON UNSATURATED MODIFIED SUGARS

Authors
PREVOST N ROUESSAC F
Citation
N. Prevost et F. Rouessac, A NOVEL ROUTE TO PYRIMIDINE ISODIDEOXYNUCLEOSIDES VIA MICHAEL-TYPE ADDITION ON UNSATURATED MODIFIED SUGARS, Synthetic communications, 27(13), 1997, pp. 2325-2335
Citations number
34
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
13
Year of publication
1997
Pages
2325 - 2335
Database
ISI
SICI code
0039-7911(1997)27:13<2325:ANRTPI>2.0.ZU;2-X
Abstract
A short, stereocontrolled synthesis of isonucleosides is described. Th is approach is based on the Michael-Type addition of silylated uracil or thymine with an appropriate acceptor as pyranoside precursor. The a lkylated products obtained allow carbonyl reduction, providing a strai ghtforward way to prepare new sugar-modified nucleosides.