SYNTHESIS AND CYTOTOXIC EVALUATION OF THE FIRST TRANS-PALLADIUM(II) COMPLEX WITH NATURALLY-OCCURRING ALKALOID HARMINE

Authors
ALALLAF TAK RASHAN LJ
Citation
Tak. Alallaf et Lj. Rashan, SYNTHESIS AND CYTOTOXIC EVALUATION OF THE FIRST TRANS-PALLADIUM(II) COMPLEX WITH NATURALLY-OCCURRING ALKALOID HARMINE, European journal of medicinal chemistry, 33(10), 1998, pp. 817-820
Citations number
19
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
33
Issue
10
Year of publication
1998
Pages
817 - 820
Database
ISI
SICI code
0223-5234(1998)33:10<817:SACEOT>2.0.ZU;2-L
Abstract
Treatment of trans-[Pd(DMSO)(2)Cl-2] with naturally occurring alkaloid harmine, in a 1:1 molar ratio in DMSO, leads to the formation of tran s-[Pd(DMSO)(harmine)Cl-2]. The latter was isolated from DMSO solution by addition of 0.05 M HCl solution. The complex has been characterized physicochemically and spectroscopically. It was tested for its cytoto xicity against P388, L-1210 and K-562 cell lines, and showed promising activity, as a first trans-palladium(II) complex, when compared with the reference standards cisplatin, carboplatin and 5-fluororuracil (5- FU). (C) Elsevier, Paris.