URACIL DNA GLYCOSYLASE SPECIFICALLY INTERACTS WITH VPR OF BOTH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND SIMIAN IMMUNODEFICIENCY VIRUS OF SOOTY MANGABEYS, BUT BINDING DOES NOT CORRELATE WITH CELL-CYCLE ARREST

Authors
SELIG L BENICHOU S ROGEL ME WU LI VODICKA MA SIRE J BENAROUS R EMERMAN M
Citation
L. Selig et al., URACIL DNA GLYCOSYLASE SPECIFICALLY INTERACTS WITH VPR OF BOTH HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 AND SIMIAN IMMUNODEFICIENCY VIRUS OF SOOTY MANGABEYS, BUT BINDING DOES NOT CORRELATE WITH CELL-CYCLE ARREST, Journal of virology, 71(6), 1997, pp. 4842-4846
Citations number
31
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
6
Year of publication
1997
Pages
4842 - 4846
Database
ISI
SICI code
0022-538X(1997)71:6<4842:UDGSIW>2.0.ZU;2-O
Abstract
The Vpr protein encoded by human immunodeficiency virus type 1 (HIV-1) is important for growth of virus in macrophages and prevents infected cells from passing into mitosis (G(2) arrest). The cellular target fo r these functions is not known, but Vpr of HIV-1 and the related Vpr f rom simian immunodeficiency virus of sooty mangabeys (STVSM) bind the DNA repair enzyme UNG, while the Vpx protein of SIVSM does not. Noneth eless, a mutational analysis of Vpr showed that binding to UNG is neit her necessary nor sufficient for the effect of Vpr on the cell cycle.