Intracoronary stents are the most widespread implants (besides tooth c
rownings). They almost eliminated the threat of abrupt vessel closure
during and after PTCA and reduced the incidence of restenosis in all t
ypes of lesions. As a result, roughly 60% of all PTCA procedures are a
ccompanied by a stent implantation. Currently, we are facing the third
generation of stents that provide more flexibility, more radial stren
gth, lower profiles and a variety of different lengths, and may be imp
lanted at moderate balloon pressures. Stent restenosis is considered t
he main issue of the remaining problems associated with PTCA. Computer
calculated stent designs, coatings with antithrombotic and antiprolif
erative compounds, coverings to act as a barrier against proliferation
, and radioactivity are being thoroughly studied to finally defeat a m
ajor iatrogenic disease: restenosis. The solution is likely to be foun
d by the end of the year 2000.