Lj. Martinez et Jc. Scaiano, CHARACTERIZATION OF THE TRANSIENT INTERMEDIATES GENERATED FROM THE PHOTOEXCITATION OF NABUMETONE - A COMPARISON WITH NAPROXEN, Photochemistry and photobiology, 68(5), 1998, pp. 646-651
The photochemical and photophysical properties of nabumetone (4-[6-met
hoxy-2-naphthyl]-2-butanone) were examined employing conventional and
time-resolved spectroscopic techniques. The naphthalene-like nabumeton
e triplet is formed with 29% efficiency in acetonitrile, Singlet oxyge
n formation was also detected in this solvent with Phi(Delta) value of
0.19. A naphthalene-like radical cation absorption, formed via biphot
onic processes, was also detected. The reactivity of both the triplet
and radical cation of nabumetone toward different substrates was exami
ned. The photochemical properties of nabumetone are compared with thos
e of naproxen, a structurally related acidic nonsteroidal anti-inflamm
atory drug. For these two anti-inflammatory agents, a type II photosen
sitization process is most likely responsible for their phototoxicity.