AN ANTIINFLAMMATORY ACTIVE FUROCHROMONE, NORCIMIFUGIN FROM CIMICIFUGA-FOETIDA - ISOLATION, CHARACTERIZATION, TOTAL SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF ITS ANALOGS

In the course of our investigation to isolate the non-steroidal antiin flammatory active (NSAIA) lead molecules from the plants. 1 methylethy l)-2,3-dihydro-5H-oxolo[3',2':4,5]-benzo [b]oxin-5-one also called as norcimifugin] has been isolated from the dichloromethane extract of rh izomes of Cimicifuga foetida. Characterization, total synthesis and an tiinflammatory activity of 1 are reported. Alkyl; ester, carbamate, am ine derivatives of 1 have been synthesized and their antiinflammatory activity assessed. Norcimifugin displayed antiinflammatory activity in the carrageenin induced paw edema model (50.4% inhibition at 50 mg/kg , p.o.).