AN ANTIINFLAMMATORY ACTIVE FUROCHROMONE, NORCIMIFUGIN FROM CIMICIFUGA-FOETIDA - ISOLATION, CHARACTERIZATION, TOTAL SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF ITS ANALOGS
B. Lal et al., AN ANTIINFLAMMATORY ACTIVE FUROCHROMONE, NORCIMIFUGIN FROM CIMICIFUGA-FOETIDA - ISOLATION, CHARACTERIZATION, TOTAL SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY OF ITS ANALOGS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 37(9), 1998, pp. 881-893
In the course of our investigation to isolate the non-steroidal antiin
flammatory active (NSAIA) lead molecules from the plants. 1 methylethy
l)-2,3-dihydro-5H-oxolo[3',2':4,5]-benzo [b]oxin-5-one also called as
norcimifugin] has been isolated from the dichloromethane extract of rh
izomes of Cimicifuga foetida. Characterization, total synthesis and an
tiinflammatory activity of 1 are reported. Alkyl; ester, carbamate, am
ine derivatives of 1 have been synthesized and their antiinflammatory
activity assessed. Norcimifugin displayed antiinflammatory activity in
the carrageenin induced paw edema model (50.4% inhibition at 50 mg/kg
, p.o.).