ANTIMITOTIC AGENTS INTERACTING WITH TUBULIN - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL ORTHO BRIDGED BIPHENYLS OF THE RHAZINILAM TYPE

Authors
PASCAL C DUBOIS J GUENARD D TCHERTANOV L THORET S GUERITTE F
Citation
C. Pascal et al., ANTIMITOTIC AGENTS INTERACTING WITH TUBULIN - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF NOVEL ORTHO BRIDGED BIPHENYLS OF THE RHAZINILAM TYPE, Tetrahedron, 54(49), 1998, pp. 14737-14756
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
54
Issue
49
Year of publication
1998
Pages
14737 - 14756
Database
ISI
SICI code
0040-4020(1998)54:49<14737:AAIWT->2.0.ZU;2-5
Abstract
Several new ortho bridged biphenyls mimicking the structure of (-)-rha zinilam were synthesized and evaluated as cytotoxic compounds and as i nhibitors of microtubules disassembly. These included azadibenzo[a,c]c yclononene derivatives having an ester, urea or carbamate function pre sent in the 9-membered ring linking the two phenyl moieties. The compo und bearing a carbamate function instead of the amide group of rhazini lam interacts better with tubulin than (-) rhazinilam, (C) 1998 Elsevi er Science Ltd. All rights reserved.