An increase in the regularity of blood donation is desirable for two m
ain reasons. First, the lower incidence of viral disease markers in re
gular donors when compared to first donors could help to reduce risks
of transmissible diseases. Second, a higher frequency of donation coul
d contribute to a more satisfactory supply of blood products. Two meas
ures implemented with the aim of increasing the regularity of blood do
nation were evaluated: (i) an increase in the annual frequency of bloo
d collection by mobile teams at collection sites, and (ii) a ''next do
nation document'' given to each donor indicating the earliest possible
date of the next donation. The regularity index was calculated as the
mean number of cellular donations (whole blood and platelet apheresis
) per donor per year, over two consecutive periods: 1-7-1993 - 30-6-19
94 (P1) and 1-7-1994 - 30-6-1995 (P2). The junction of these two perio
ds corresponded to the date of introduction of the ''next donation doc
ument'' and to the time of reinforcement of the mobile collection freq
uency. First donors in either period were not taken into account in th
e study. A significant relationship was observed between the annual fr
equency of mobile collection and the average number of donations per d
onor (comparison test of two means on large samples, p < 0.001 in all
the cases excepted those of stable mobile collection numbers). Thus, i
n the first period, the average donation rate was the lowest on sites
having only one mobile collection per year (M: 1.55, W: 1.38) and the
highest on sites with five mobile collections per year (M: 2.05, W: 1.
71). These average numbers significantly increased in the second perio
d as compared to the first (M: + 4.8 %, W: + 1.8%; comparison test of
two means from paired series, p < 0.001), as did the yearly frequency
of mobile blood collections (+ 9.2%). On the other hand, the ''next do
nation document'' was not associated to any change in the regularity i
ndex. The results of this study therefore showed an increase in the fr
equency of visits of mobile collection teams to be the main factor lea
ding to an improvement in the regularity of blood donation. Moreover,
this evolution was associated with a decrease in the incidence of vira
l markers detected at donation. (C) 1998 Elsevier, Paris.