RESISTANCE TO PENICILLIN-G AND OUTCOME FROM PNEUMOCOCCAL INFECTION, IN FOCH-HOSPITAL, PARIS AREA, FRANCE

Citation
S. Mouly et al., RESISTANCE TO PENICILLIN-G AND OUTCOME FROM PNEUMOCOCCAL INFECTION, IN FOCH-HOSPITAL, PARIS AREA, FRANCE, Annales de medecine interne, 149(6), 1998, pp. 323-325
Citations number
6
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
0003410X
Volume
149
Issue
6
Year of publication
1998
Pages
323 - 325
Database
ISI
SICI code
0003-410X(1998)149:6<323:RTPAOF>2.0.ZU;2-3
Abstract
Decreased suceptibility to penicillin G of pneumococcal strains is con tinuously increasing-in France. Objective. - We assessed effect of res istance to penicillin on therapeutic management and mortality in adult s with pneumococcal pneumonia in our hospital. Methods. - This one-yea r retrospective study (1995) included patients with proven pneumococca l infection (positive bloodculture, pleural fluid, or specimens from t he lower respiratory tract). Strains of Streptococcus pneumoniae were screened for suceptibility to antimicrobial agents. Resistance to peni cillin G was defined as a minimal inhibitory concentration greater tha n or equal to 0.12 mu g/ml. Age immune and nosocomial status, first an d second line antibiotherapy and death were compared according to the strains suceptibility to penicillin G. A p value below 0.05 was statis tically significant. Results. - In 15 cases a pneumococcal strain suce ptible to penicillin G was isolated while 23 patients were infected Ki th a strain with a decreased suceptibility to penicillin G. Age was si gnificantly higher in the latest group (61.6 versus 54.7 years) while no difference was noted between the 2 groups according to immune and n osocomial status, therapeutic management and death. Discussion. - Resi stance to penicillin did neither appear to increase mortality nor to i nfluence therapeutic managment in patients with pneumococcal infection .