A SIMPLE AND EFFICIENT SYNTHESIS OF 1,6-DISUBSTITUTED 1,4,5,6-TETRAHYDROPYRIDAZINES BY RING ENLARGEMENT OF 2,5-DIBENZOTRIAZOLYL-N-AMINOPYRROLIDINES

Authors
KATRITZKY AR PLEYNET DPM YANG BZ YAO JC
Citation
Ar. Katritzky et al., A SIMPLE AND EFFICIENT SYNTHESIS OF 1,6-DISUBSTITUTED 1,4,5,6-TETRAHYDROPYRIDAZINES BY RING ENLARGEMENT OF 2,5-DIBENZOTRIAZOLYL-N-AMINOPYRROLIDINES, Synthesis, (11), 1998, pp. 1627-1630
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
11
Year of publication
1998
Pages
1627 - 1630
Database
ISI
SICI code
0039-7881(1998):11<1627:ASAESO>2.0.ZU;2-G
Abstract
1,6-Disubstituted 1,4,5,6-tetrahydropyridazines 3a-l are readily acces sible in good to high yields by Grignard reagent induced ring enlargem ent of 2,5-dibenzotriazolyl-N-arylaminopyrrolidines 2a-c. Compounds 2a -c are prepared in high yields by reaction of benzotriazole with succi nic dialdehyde and the corresponding arylhydrazines.