M. Largeron et Mb. Fleury, A CONVENIENT 2-STEP ONE-POT ELECTROCHEMICAL SYNTHESIS OF NOVEL 8-AMINO-1,4-BENZOXAZINE DERIVATIVES POSSESSING ANTISTRESS OXIDATIVE PROPERTIES, Tetrahedron letters, 39(49), 1998, pp. 8999-9002
Using (3,4-hydroxy-2-methoxyphenyl) (phenyl) methanone as the starting
material, the reaction of the electrogenerated 3,4-quinone with amino
alcohols leads to the transient 1,4-benzoxazin-8-one species. The lat
ter can undergo a subsequent addition reaction of an amine at the 8-po
sition affording, after electrochemical reduction, novel 8-amino-1,4-b
enzoxazine derivatives. The entire sequence can be conducted in one-po
t, without isolation of intermediates. (C),1998 Elsevier Science Ltd.
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