A CONVENIENT 2-STEP ONE-POT ELECTROCHEMICAL SYNTHESIS OF NOVEL 8-AMINO-1,4-BENZOXAZINE DERIVATIVES POSSESSING ANTISTRESS OXIDATIVE PROPERTIES

Using (3,4-hydroxy-2-methoxyphenyl) (phenyl) methanone as the starting material, the reaction of the electrogenerated 3,4-quinone with amino alcohols leads to the transient 1,4-benzoxazin-8-one species. The lat ter can undergo a subsequent addition reaction of an amine at the 8-po sition affording, after electrochemical reduction, novel 8-amino-1,4-b enzoxazine derivatives. The entire sequence can be conducted in one-po t, without isolation of intermediates. (C),1998 Elsevier Science Ltd. All rights reserved.