EFFECTS OF CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS AND KIDNEY-TRANSPLANTATION ON ADVANCED GLYCATION ENDPRODUCTS IN THE SKIN AND PERITONEUM

Advanced glycation endproducts (AGE) form as a result of non-enzymatic reaction of reducing sugars with proteins. Patients with chronic rena l failure (CRF) have elevated AGE in plasma, skin and peritoneum. We m easured AGE in the skin and peritoneum of individuals with CRF, patien ts undergoing continuous ambulatory peritoneal dialysis (CAPD) and in renal transplant recipients (TR). Pentosidine concentration and collag en-linked fluorescence (CLF) were measured. Pentosidine and CLF correl ated in all patient groups (CRF r=0.688, p<0.01; CAPD r=0.674, p<0.05; TR r=0.811, p<0.01). Successful kidney transplant reduced AGE levels in the skin (CRF 11.7 +/- 4.51 U/mg; TR 5.02 +/- 3.13 U/mg, p<0.00001) and peritoneum (CRF 17.5 +/- 6.16 U/mg, TR 9.4 +/- 4.97 U/mg, p<0.000 1). However in contrast to the TR group, CLF in peritoneum increased f ollowing CAPD (CRF 17.5 ir 6.16 U/mg; CAPD 24.2 +/- 10.4U/mg; p=0.06). Our results suggest that AGE might be formed in the peritoneum during CAPD treatment.