CHARACTERIZATION OF A NOVEL AGE-COMPOUND DERIVED FROM LYSINE AND 3-DEOXYGLUCOSONE

Dicarbonyl compounds are supposed to be reactive intermediates in the non-enzymatic glycation of proteins. A process that eventually could l ead to the development of late diabetic complications. Glyoxal lysine dimer (GOLD) and methylglyoxal lysine dimer (MOLD) have previously bee n described as such reactive dicarbonyls. Here a new compound 3-deoxyg lucosone lysine dimer (DOLD), a cross-link resulting from the reaction between hippuryl-lysine and 3-deoxyglucosone, has been isolated by HP LC and the structure determined by mass spectrometry and NMR.