The higher prevalence of depression in women is coupled with a higher
prevalence of pain complaints. Growing evidence suggests that the como
rbidity of these conditions is also proportionately higher in women th
an men. This paper critically reviews the empirical findings relating
to gender differences in comorbid pain and depression as well as findi
ngs in support of hypothesized etiologic factors that could explain wh
y women may be more susceptible than men to comorbidity. The empirical
evidence for biogenic, psychogenic, and sociogenic explanatory models
is presented, and an integration of these models is proposed as a gui
deline to both research and clinical practice. In conclusion, it is ar
gued that gender-differentiated treatment strategies are not clinicall
y indicated at this time.