F. Guibal et al., EFFECTS OF DICLOFENAC ON EXPERIMENTAL STREPTOCOCCAL NECROTIZING FASCIITIS (NF) IN RABBIT, Archives of dermatological research (Print), 290(11), 1998, pp. 628-633
Aggravation of necrotizing fasciitis (IVF) by the administration of no
n-steroidal antiinflammatory drugs (NSAIDs) has recently been suggeste
d. A rabbit model of streptococcal NF was used to study the effects of
parenteral administration of an NSAID on NF evolution and outcome. Of
16 rabbits inoculated with a Streptococcus pyogenes suspension togeth
er with staphylococcal alpha toxin, 8 were treated with two doses of 4
mg/kg diclofenac on day 1 after inoculation. Clinical, bacteriologica
l and histological studies were performed until day 10, Under our expe
rimental conditions, NSAID treatment significantly limited NF extensio
n. A specific inverse relationship between the extent of inflammation
and bacterial density in NF lesions was observed on day 1 after inocul
ation in the treated group suggesting that the greater severity of NF
in humans treated with an NSAID could be due to the therapeutic delay
induced by the misleading clinical effects of the NSAID, and not to in
hibition of antibacterial defence.