THE EFFECT OF COFFEE AND CAFFEINE CONSUMPTION ON SERUM-LIPIDS IN RATS

This study was carried out on the male adult Wistar-Albino rats in ord er to investigate the effects of coffee and caffeine consumption on se rum lipids in atherogenic and normal diets. Fifty rats were divided in to five groups and each group was fed with the following diets: first group was a control group and fed with the standard chow diet, coffee, caffeine, cholesterol and cholesterol plus coffee were added to secon d, third, fourth, and fifth groups, respectively. The results indicate d that the consumption of coffee alone had no effect on serum lipids. However the addition of coffee to a hypercholesterolemic diet signific antly increased the effect on serum total cholesterol (P < 0.01), trig lycerides (P < 0.05), VLDL-cholesterol (P < 0.05), LDL-cholesterol (P < 0.01), and HDL-cholesterol (P < 0.01) levels. Adding caffeine to nor mal diet resulted in an increase in serum total cholesterol (P < 0.01) . Despite these increases, the ratio of HDL-cholesterol to total chole sterol and LDL-cholesterol remained unchanged. The results indicated t hat coffee could not be considered alone as a risk factor for coronary heart disease.