In this article, nature derived collagen was mixed with chitosan and c
rosslinked by formaldehyde to form a homogeneous composite membrane. T
he microstructure of the composite was characterized by transmission e
lectron microscopy and differential scanning calorimetry. Mechanical a
nd swelling properties of the composite were improved compared with pu
re collagen and can be modulated via changing the crosslinking conditi
ons, such as pH, time, and concentration. (C) 1997 John Wiley & Sons,
Inc.