A NON-DIPLOID, SMALL-CELL CARCINOMA OF THE OVARY OF THE HYPERCALCEMICTYPE

Small cell carcinoma of the ovary is a rare, highly malignant tumor th at occurs typically in young females. It usually manifests as a solid, unilateral adnexal mass which is in approximately 75% of cases accomp anied by paraneoplastic hypercalcemia. We report a case of ovarian sma ll cell carcinoma and describe the clinical, histological and immunohi stochemical features. The tumor was p53, MIB-1, vimentin, epithelial m embrane antigen and prekeratin positive and bcl-2 and S-100 negative. Despite the highly malignant behavior of this tumor, all reported case s have hitherto been diploid. This case is the first reported non-dipl oid small cell carcinoma of the ovary.