CHRONIC EOSINOPHILIC LEUKEMIA AND HYPEREOSINOPHILIC SYNDROMES - PROPOSAL FOR CLASSIFICATION, LITERATURE-REVIEW, AND REPORT OF A CASE WITH AUNIQUE CHROMOSOMAL ABNORMALITY

The idiopathic hypereosinophilic syndromes (HES) are rare hematologic disorders characterized by persistent eosinophilia with organ involvem ent that encompass a wide spectrum of clinical and hematological disea se states. We propose a classification scheme to further delineate the se patients, and present a case of a 45-year-old male with persistent eosinophilia, ser ere tissue and hematologic involvement, and trisomy 15. Although multiple cytogenetic abnormalities have been associated w ith hypereosinophilic syndromes, this is the first reported case where trisomy 15 is the sole chromosomal abnormality. (C) Elsevier Science Inc., 1998.